Having developed an interest in human evolution and its application to medicine as an undergraduate at the University of California at Santa Barbara, followed by medical education at the University of Southern California culminating in certification in endocrinology and metabolism with research interest in bone, a field study (medical practice) was initiated in Reno NV in 1980. The goal of discovering and modeling complex causal relationships governing human health has been principled upon the Phosphate Hypothesis that posits phosphate to be the fundamental signal organizing energy into phenotypes. The project lead to a general theory of metabolism based on the intracellular processing of glucose and the role of heat that informs a discipline of Structural Ecology committed to the creation of structural equation models useful for the translation of science to clinical care derived from informative cases. The anthropologic perspective clarifies both the successes and failures of risk factor management that became the dominant business model of healthcare during the time of the field study. It was recognized early that the genome would function not as a blueprint, but more as a library for evolved adaptive strategies that could be explored utilizing simple challenge tests that expose the variance between individual patients even if similarly categorized by risk factors. The work has been presented mostly in abstract and poster presentations to the American Society for Bone and Mineral Research, Stanford Medicine X and the Center for Disease Control’s division of Diabetes where it was titled Ethical Practice as a Translational Strategy. Most recently the problem of Chronic Fatigue Syndrome has been addressed at the IACFS/ME meeting in 2016 where the absence of risk factors has compromised study of this condition even though it has been established to be physical in nature. The general theory and structural ecology are providing insights to effective treatment.
Company/Affiliation: Endocrine Associates
Industry: Private practice
Interest: Discovery of authentic causal relationships governing metabolic health focusing on the role of the skeleton as both a record and mediator of metabolism. Particular attention is given to those conditions traditionally considered to be endocrine problems and others where understanding the metabolic basis of the phenotypes will be useful including cardiovascular and fatigue syndromes.